
Discover more with a powerful, open science data platform
Developed for bench biologists and bioinformaticians, The Department of Energy Systems Biology Knowledgebase (KBase) is a software and data science platform designed to meet the grand challenge of systems biology: predicting and designing biological function.

Analyze private data in the context of public data with leading open-source tools powered by high-performance computing.
Create a free account and begin exploring what KBase can do for your research.

Capture your discoveries in a Narrative, an interactive digital notebook that can be shared with the world.
Manage data access and sharing across your project, laboratory, or institution.

Keep data private until you’re ready to share with the public.
Version-controlled apps and data provenance allow you to track your data.

Why KBase?
KBase is the first large-scale data science platform that enables users to upload their own data, analyze it alongside collaborator and public data, build increasingly realistic models, and share and publish reproducible workflows and conclusions.
KBase integrates data and tools in a unified graphical interface. Users no longer need to do analyses across multiple systems in order to create and run sophisticated systems biology workflows. KBase allows users to perform large-scale analyses and combine multiple lines of evidence to model plant and microbial physiology and community dynamics.

Read about KBase in Nature Biotechnology*
For a comprehensive overview of KBase and its scientific impact, this publication details the unique features and infrastructure of the KBase platform through several scientific use cases.

Looking for information on tools and resources?
Check out KBase Documentation for our Getting Started guide and information on tools in the App Catalog. KBase is a fully open source software project available on GitHub.