Welcome to KBase

The knowledge creation and discovery environment for systems biology.

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Discover more with a powerful, open science data platform

Discover more with a powerful, open science data platform

Developed for bench biologists and bioinformaticians, The Department of Energy Systems Biology Knowledgebase (KBase) is a software and data science platform designed to meet the grand challenge of systems biology: predicting and designing biological function.

TECHNOLOGY
TECHNOLOGY
Data Science Platform

Analyze private data in the context of public data with leading open-source tools powered by high-performance computing.

Free and Easy to Use

Create a free account and begin exploring what KBase can do for your research.

COMMUNITY
COMMUNITY
Reproducible Science

Capture your discoveries in a Narrative, an interactive digital notebook that can be shared with the world.

Collaborative Research

Manage data access and sharing across your project, laboratory, or institution.

STEWARDSHIP
STEWARDSHIP
Control Your Data

Keep data private until you’re ready to share with the public.

Data Tracking

Version-controlled apps and data provenance allow you to track your data.

Why KBase?

Why KBase?

KBase is the first large-scale data science platform that enables users to upload their own data, analyze it alongside collaborator and public data, build increasingly realistic models, and share and publish reproducible workflows and conclusions.

KBase integrates data and tools in a unified graphical interface. Users no longer need to do analyses across multiple systems in order to create and run sophisticated systems biology workflows. KBase allows users to perform large-scale analyses and combine multiple lines of evidence to model plant and microbial physiology and community dynamics.

Getting started with KBase
Getting started with KBase

Getting started with KBase

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Read about KBase in Nature Biotechnology*

Read about KBase in Nature Biotechnology*

For a comprehensive overview of KBase and its scientific impact, this publication details the unique features and infrastructure of the KBase platform through several scientific use cases.

*How to cite: Arkin AP, Cottingham RW, Henry CS, et al. KBase: The United States Department of Energy Systems Biology Knowledgebase. Nature Biotechnology. 2018;36: 566. doi: 10.1038/nbt.4163
Looking for information on tools and resources?

Looking for information on tools and resources?

Check out KBase Documentation for our Getting Started guide and information on tools in the App Catalog. KBase is a fully open source software project available on GitHub.

Narrative maintenanceNarrative maintenance 2021 Jan 19

We will be performing maintenance on narrative.kbase.us on Tuesday, January 19, 2021, from 2-4pm PST (4-6pm CST).  Parts of narrative.kbase.us will be unavailable during this time.

System maintenanceSystem maintenance 2021 Jan 21

We will be performing system maintenance on Thursday, January 21, 2021, from 2-5pm PST (4-7pm CST).  narrative.kbase.us and compute jobs will be unavailable or broken during this time.  For more information, please see https://www.kbase.us/migration-to-new-data-backend/ .  (www.kbase.us will not be impacted by this maintenance.)