Exploring Plant Gene Linkages using Random Walk with Restart Tools in KBase

Presenter: Kyle Sullivan, Oak Ridge National Laboratory

Wednesday, January 31 at 1pm ET/10am PT

This webinar will showcase a new suite of tools for building and exploring gene-to-gene multiplex networks of ‘omics features using KBase. The new RWRtools module introduces two tools that use a Random Walk with Restart (RWR) algorithm for exploring gene-to-gene multiplex networks in Arabidopsis from multiple lines of evidence, including protein-protein interactions, metabolic reactions, transcription factor regulation, and predictive expression/epigenetic networks with up to exascale-complexity computed by DOE supercomputers. By identifying Arabidopsis orthologs from non-model plant species, the Lines of Evidence app performs RWR on Arabidopsis networks to find the functional context of a user’s gene set, whereas the Cross Validation app uses RWR to find the interconnectivity of a user’s gene set. These apps were developed by Dan Jacobson’s Team at Oak Ridge National Laboratory and deployed into KBase with support from DOE Biological and Environmental Research.

Register for the webinar using the link below. Note that you must use an  email account registered with Zoom for authentication purposes.